The Partnership for HIV-Free Survival (PHFS) was a multi-country collaboration to accelerate implementation of the World Health Organization’s (WHO) 2010 guidelines on the prevention of mother-to-child transmission (PMTCT) of HIV/AIDS, which focused on infant feeding in the context of HIV care and treatment. Launched by WHO and the United States President’s Emergency Plan for AIDS Relief (PEPFAR) through USAID and the Centers for Disease Control and Prevention (CDC), the initiative was implemented between 2012 and 2014 in six countries with a high HIV burden: Kenya, Lesotho, Mozambique, South Africa, Tanzania, and Uganda. The initiative’s overall goal was to increase HIV-free survival of infants born to HIV-infected mothers.